Table 2.
The 56 skin ageing phenotypes.
| Phenotype ID | Skin ageing phenotype |
|---|---|
| A1 | Absence of fat tissue/reduced fat tissue |
| A2 | Cheek skin pores appear larger |
| A3 | Coarse wrinkles on cheek/coarse cheek folds |
| A4 | Cris-cross wrinkles/perioral wrinkles/perioral lines/lip wrinkles |
| A5 | Cutis rhomboidalis nuchae |
| A6 | Deep wrinkles/coarse wrinkles/lateral canthal lines/crow’s feet |
| A7 | Droopy eye(s)/ptosis of eyelids |
| A8 | Eyebags |
| A9 | Favre-Racouchot syndrome |
| A10 | Fine lines on cheek/fine cheek folds |
| A11 | Forehead wrinkles/forehead lines |
| A12 | Glabellar lines/forehead furrows |
| A13 | Horizontal interocular wrinkles |
| A14 | Lax appearance/tissue slacking |
| A15 | Low brow positioning |
| A16 | Lower lip fullness |
| A17 | Melomental folds/Marionette lines/drooping of labial commissures |
| A18 | Nasolabial folds |
| A19 | Pseudoscar/pseudo scar/stellate pseudoscar |
| A20 | Sagging of jawline |
| A21 | Sagging or wrinkling of the neck skin or having an obtuse cervicomental angle |
| A22 | Solar elastosis/actinic elastosis/elastosis senilis |
| A23 | Superficial wrinkles/fine wrinkles/lateral canthal lines/crow’s feet |
| A24 | Upper lip fullness |
| A25 | Wrinkles (detected by shaded lines on the face) |
| A26 | Wrinkles under eyes/periorbital wrinkles upper cheek area |
| A27 | Xerosis/asteatotic dermatitis/higher TEWL |
| B1 | Facial pigmented spots (detected by polarised light capturing the skin surface) |
| B2 | Facial pigmented spots (detected by UV light capturing the inside of the epidermis) |
| B3 | Freckles/sunburn freckles/ephelides |
| B4 | Guttate hypomelanosis |
| B5 | Melasma |
| B6 | Milia |
| B7 | Perceived skin darkness |
| B8 | Permanent erythema/skin flushing |
| B9 | Sebaceous hyperplasia |
| B10 | Seborrheic keratosis/benign skin tumours |
| B11 | Senile comedone/senile comedo/solar comedo/periorbital comedone |
| B12 | Senile purpura |
| B13 | Skin colour/skin colour (extent of darkness)/lower reflectance skin (darker skin than normal, higher melanin content) |
| B14 | Skin type—sun sensitivity/skin sensitivity to the Sun |
| B15 | Skin type—tanning type/inability to tan/burn rather than tan/sunburn type |
| B16 | Solar lentigines/solar lentigo/senile lentigo/lentigo senilis/age spot/liver spot/pigment spots (darkness) |
| B17 | Telangiectasias |
| B18 | Uneven pigment/uneven pigmentation/pigment spot |
| B19 | Venous lakes |
| B20 | Yellowish decolouration/yellowness |
| C1 | Actinic keratosis/actinic precancerosis/solar keratosis |
| C2 | Basal cell carcinoma/cutaneous basal cell carcinoma |
| C3 | Malignant melanoma/cutaneous malignant melanoma/melanoma |
| C4 | Non-melanoma skin cancer |
| C5 | Squamous cell carcinoma/cutaneous squamous cell carcinoma of the skin |
| D1 | Different gene expression in young skin compared to aged skin, the influence of this SNP changes with age (increase/decrease) |
| D2 | Facial skin is more youthful than normal |
| D3 | Global facial photoageing |
| D4 | Perceived age is different from actual age (older than/younger than) |
Varying terminology used by different studies for identical phenotypes are separated by a slash (/).