Table 4.
Differentially expressed skin colour genes associated with chronological age.
| Skin ageing gene | GEO dataset study IDa | Ratio definitionb | Expression ratio | p-Value |
|---|---|---|---|---|
| AGR3 | GSE181022 | Non-infant/infant | 1.17 | 8.71E−09 |
| GSE85358 | Naturally aged skin/young skin | 1.15 | 3.47E−04 | |
| BNC2 | GSE181022 | Non-infant/infant | 0.90 | 3.58E−03 |
| GSE85358 | Naturally aged skin/young skin | 0.98 | 5.57E−03 | |
| DSTYK | GSE181022 | Non-infant/infant | 1.21 | 3.75E−05 |
| GSE102676 | Solar stimulated UV radiation/untreated | 1.12 | 5.78E−03 | |
| GSE85358 | Naturally aged skin/young skin | 1.03 | 2.86E−02 | |
| EDNRB | GSE181022 | Non-infant/infant | 0.69 | 6.27E−16 |
| GSE44805 | Melanoma skin/non-melanoma skin | 0.56 | 6.94E−03 | |
| MC1R | GSE181022 | Old age/young adult | 0.96 | 1.23E−02 |
| GSE44805 | Melanoma skin/non-melanoma skin | 0.89 | 1.13E−02 | |
| SHC4 | GSE181022 | Non-infant/infant | 0.90 | 4.58E−08 |
| GSE44805 | Melanoma skin/non-melanoma skin | 0.70 | 2.07E−03 | |
| TPCN2 | GSE181022 | Non-infant/infant | 1.05 | 1.24E−05 |
| GSE102676 | Solar stimulated UV radiation/untreated | 1.21 | 3.98E−02 | |
| GSE85358 | Naturally aged skin/young skin | 1.02 | 1.89E−02 | |
| TYR | GSE181022 | Non-infant/infant | 0.74 | 6.63E−03 |
| GSE44805 | Melanoma skin/non-melanoma skin | 0.39 | 1.65E−08 |
aGSE181022 controls for sun exposure by using only sun-protected skin. The skin tissue in GSE85358 is skin aged normally, which will typically be exposed concurrently to numerous factors (e.g., chronological age and sun exposure).
bThe expression ratio is the average expression level in the aged tissue or tissue with skin ageing phenotypes (i.e., cases) divided by (/) the average expression level in the young tissue or tissue without skin ageing phenotypes (i.e., reference). Ratios above 1 indicate higher expression levels in the cases group while ratios below 1 indicate lower expression levels in the cases group.