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. 2022 Jul 30;12:13135. doi: 10.1038/s41598-022-17446-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ym155 decreases glucose 2-carbon transfer in the TCA cycle. H1299 cells were loaded with [U13C6] glucose for 2 h then treated with Ym155 for 3 h. (A, B) The number 3 carbons (M + 3) in glycolysis intermediates pyruvate and lactate was the same between Ym155 treated and control. (D) The TCA cycle intermediate isocitrate, alpha-ketoglutarate, fumarate, and malate had significantly lower M + 2 carbons in Ym155 treated cells compared to controls (C–F).