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. 2022 Jul 30;13:4435. doi: 10.1038/s41467-022-32176-5

Fig. 2. Alternaria-challenged Rbm3−/− mice exhibit significant increases in airway granulocytes, inflammation, and Th2 cytokines.

Fig. 2

Wild-type and Rbm3−/− mice were challenged with 10 µg Alternaria three times over 7 days. Data shown are representative of 3 experiments (4 mice per group). a Total BAL (p = 0.0036) and lung eosinophils (p = 0.0083). Representative FACS plots of WT and Rbm3−/−mice. Mann-Whitney Test, two-tailed. b Total BAL (p = 0.0001) and lung (p = 0.0001) neutrophils. Representative FACS plots of WT and Rbm3−/− mice. Statistics analyzed by Mann-Whitney Test, two-tailed. Wild-type and Rbm3−/− mice were challenged with 20 µg and 10 µg Alternaria over the span of 10 days. Data shown are representative of 4 experiments (4 mice per group). c Total BAL (p = 0.0001) and lung (p = 0.0148) eosinophils. Mann-Whitney Test, two-tailed. d Total BAL (p < 0.0001) and lung (p = 0.2087) neutrophils. Unpaired t-test, two-tailed. e BAL levels of Type 2 cytokines (IL-13 p = 0.0005 and IL-5 p = 0.0036). Mann-Whitney Test, two-tailed. f H&E and PAS lung sections at 20X; scale bar is 100 µm. Airway images representative of 4 mice per group. *p < 0.05, ** p < 0.01, ***p < 0.001, ****p < 0.0001. Data are presented as mean values+/− SEM.