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. 2022 Jul 30;12:13131. doi: 10.1038/s41598-022-16274-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The cytotoxicity assessment of curcuminoid analogues (FLDP-5 and FLDP-8) and curcumin on LN-18 cells. (A) Cytotoxicity of FLDP-5 and FLDP-8 curcuminoid analogues treated LN-18 cells with concentrations from 0.625 μM till 20 μM was observed after 24-h treatment. IC₅₀ values of 2.4 μM and 4 μM were observed respectively in FLDP-5 curcuminoid analogues and FLDP-8. (B) Cytotoxicity of curcumin-treated LN-18 cells with concentrations from 3.125 μM till 100 μM was observed after 24-h treatment. An IC₅₀ value of 31 μM was observed. Each data point was obtained from three independent experimental replicates and expressed as mean ± SEM of percentage of cell viability. *p < 0.05 against negative control (untreated cell).