Table 3.
Variable
|
Survival time
|
Univariate
|
Multivariate
|
|||
---|---|---|---|---|---|---|
Mean ± SD (Months) |
HR (95% CI) |
P-value | HR (95% CI) |
P-value | ||
Sex | Male | 58.06 ± 6.38 | 0.76 (0.41-1.40) | 0.38 | ||
Female | 42.97 ± 4.91 | 1 | ||||
Age group of patients | ≤ 30 | 52.69 ± 6.76 | 1.11 (0.61-2.04) | 0.73 | ||
> 30 | 53.98 ± 5.94 | 1 | ||||
Diseases status at transplant |
CR1 | 54.34 ± 4.56 | 0.69 (0.17-2.87) | 0.61 | ||
CR2 | 20.52 ± 8.71 | 1 | ||||
WBC (×108 /ml) | <5 | 68.94 ± 5.82 | 1 | 1 | ||
5-10 | 26.00 ± 6.8 | 2.97 (1.23-7.19) | 0.02* | 2.76 (1.13-6.72) | 0.03* | |
>10 | 22.09 ± 6.77 | 4.06 (1.88-8.80) | <0.001* | 3.98 (1.84-8.63) | <0.001* | |
Donor relative | Sibling | 55.91 ± 4.67 | 0.48(0.20-1.14) | 0.09 | ||
Related alternative | 14.63 ± 4.61 | 1 | ||||
Relapse | Yes | 25.11 ± 9.45 | 2.61 (1.28-5.34) | 0.008* | 5.66 (2.6-12.34) | <0.001* |
No | 57.94 ± 4.79 | 1 | 1 | |||
Age group of donors | ≤ 30 | 58.13 ± 6.86 | 0.82 (0.43-1.54) | 0.53 | ||
> 30 | 48.15 ± 5.51 | 1 | ||||
Sex of donor - recipient | F-F | 47.70 ± 7.11 | 1.35 (0.58-3.14) | 0.48 | ||
F-M | 59.45 ± 9.21 | 0.91 (0.36-2.32) | 0.85 | |||
M-F | 42.27 ± 6.37 | 1.18 (0.51-2.73) | 0.70 | |||
M-M | 57.3 ± 8.28 | 1 | ||||
AML | M3 | 20.55 ± 7.49 | 1.15(0.28-4.76) | 0.84 | ||
Non-M3 | 54.00 ± 4.58 | 1 | ||||
Different types of ALM | M2 | 34.62 ± 9.11 | 10.3 (0.13-0.68) | 0.04* | 0.56 (0.21-1.49) | 0.25 |
M4 | 61.24 ± 6.43 | 1 | 1 | |||
M5 | 56.66 ± 7.89 | 0.51 (0.23-1.10) | 0.09 | 0.72 (0.32-1.61) | 0.42 |
Acute graft-versus-host diseases (aGVHD), chronic graft-versus-host diseases (cGVHD), first and second complete remission (CR1, CR2)