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. Author manuscript; available in PMC: 2022 Jul 31.
Published in final edited form as: Curr Opin Struct Biol. 2022 Feb 17;73:102335. doi: 10.1016/j.sbi.2022.102335

Figure 1. TFIID organization and interactions with DNA.

Figure 1.

A. Binding sites for TFIID lobes on promoter DNA. Lobe C binds the MTE/DPE elements. The Inr element is associated with the TAF1 HMG domain. TBP binds the upstream TATA element (PDB ID 7EGJ)[16].

B-C. TFIID lobe A is highly mobile. In panel B, lobe A is associated with TBP at the TATA site (PDB ID 7EGD) [16]. In panel C, lobe A has rotated and lies next to lobe B/C (PDB ID 7EGJ) [16]. The position of lobe A as seen in panel B is shown as a lime green surface.