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. 2022 Jul 30;22:293. doi: 10.1186/s12890-022-02090-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Evaluation of STAS. A, B Diagnosis of STAS by hematoxylin & eosin staining. STAS (arrowheads) was located within the normal alveolar lumen, outside the margin (black dashed line) of the main tumor. Further, STAS ≤ 3 alveolae away from the main tumor were classified as limited (A), STAS > 3 alveolae away from the main tumor were classified as limited extensive (B). C STAS was identified by immunohistochemistry. STAS (arrowheads, Napsin A positive) was located within the normal alveolar lumen, outside the margin (black dashed line) of the main tumor. STAS: tumor spread through air spaces