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. 2022 Jul 31;26:231. doi: 10.1186/s13054-022-04107-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Probability of survival. Kaplan–Meier graph censored at 180 days indicating probability of survival in subgroups of vasopressor support on admission, stratified according to temperature intervention. No-vasopressor support, mean arterial blood pressure (MAP) ≥ 70 with no inotropic or vasopressor support; moderate-vasopressor support, MAP < 70 or any dose dopamine, or dobutamine, or noradrenaline/adrenaline dose ≤ 0.25 µg/kg/min; and high-vasopressor support, noradrenaline/adrenaline dose > 0.25 µg/kg/min. Colored numbers at bottom of plot illustrate number of patients at risk in respective strata at specified timepoint. The vertical tick-marks correspond to censored data. Hazard ratios (HR) are presented with 95% confidence intervals; TTM33, targeted temperature management at 33 °C