Fig. 4.

Hemodynamics 0–72 h. Heart rate, mean arterial pressure, and lactate during the 0–72 h after randomization in groups of different levels of circulatory support on admission and stratified by temperature intervention at 33 °C versus normothermia. No-vasopressor support, mean arterial blood pressure (MAP) ≥ 70 with no inotropic or vasopressor support; moderate-vasopressor support, MAP < 70 or any dose dopamine, or dobutamine, or noradrenaline/adrenaline dose ≤ 0.25 µg/kg/min; and high-vasopressor support, noradrenaline/adrenaline dose > 0.25 µg/kg/min. Boxes represent the interquartile range (IQR), with medians marked as vertical bands. Whiskers symbolize 1.5 × IQR, and dots outside this range represent outliers. TTM33; Targeted temperature management at 33 °C. *p < 0.003; **p < 0.0001; ***p < 0.00001