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Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Dec 23;110(1):11–20. doi: 10.1016/j.ijrobp.2020.11.020

Figure 4. — Results of bootstrap analysis. Each point is D₅₀ and γ₅₀ calculated for a sample of patient obtained by random sampling with replacement, 2000 histories were ran. Panel A: Zoomed-in view showing a restricted range of D50 and γ₅₀. LL areas calculated as MLL minus 0.495 (violet), 1.353 (orange) and 1.92 (grey), which are chi-square values for 1 degree of freedom divided by 2 for p=0.68, 0.90 and 0.95. Model parameter values best fitting the data are shown as black solid line, dashed lines are 95% CIs for the model parameters. The 100 red points reflect the 5% of the data which contribute the least to the CI within the MLD range 0-12Gy. Panel B: Zoomed-out view, with wider range of D50 and γ₅₀ (dotted lines reflect the data range in panel A), with full results of bootstrap analysis. The legend shows CI for model parameters calculated using bootstrap.

Figure 4. — Results of bootstrap analysis. Each point is D₅₀ and γ₅₀ calculated for a sample of patient obtained by random sampling with replacement, 2000 histories were ran. Panel A: Zoomed-in view showing a restricted range of D50 and γ₅₀. LL areas calculated as MLL minus 0.495 (violet), 1.353 (orange) and 1.92 (grey), which are chi-square values for 1 degree of freedom divided by 2 for p=0.68, 0.90 and 0.95. Model parameter values best fitting the data are shown as black solid line, dashed lines are 95% CIs for the model parameters. The 100 red points reflect the 5% of the data which contribute the least to the CI within the MLD range 0-12Gy. Panel B: Zoomed-out view, with wider range of D50 and γ₅₀ (dotted lines reflect the data range in panel A), with full results of bootstrap analysis. The legend shows CI for model parameters calculated using bootstrap.