Skip to main content
. Author manuscript; available in PMC: 2023 Jul 21.
Published in final edited form as: Cell. 2022 Jul 8;185(15):2657–2677. doi: 10.1016/j.cell.2022.06.016

Figure 2. Major glycan classes in mammals.

Figure 2.

(A) O-GlcNAcylation is the dynamic and reversible addition of N-acetylglucosamine to Ser and Thr residues on thousands of intracellular proteins.

(B) O-GalNAc or mucin-like glycans are a broad class of O-linked extracellular glycans categorized by one of eight core structures that can be elaborated with a number of glycan antigens.

(C) N-glycans are branched glycans attached to Asn residues of extracellular proteins and are categorized by the number and composition of their antennae branching from a conserved core structure.

(D) Glycosaminoglycans (GAGs) are linear extracellular polysaccharides that can be sulfated at different hydroxyl and amine positions along the length of the glycan chain.