Fig. 1.

FMRP has a highly conserved role to promote translation in Drosophila oocytes and the mouse cortex. a) Volcano and b) box plots showing concordantly diminished translation efficiency of mRNAs with long CDS regions in FMRP-deficient Drosophila oocytes (Greenblatt and Spradling 2018) and mouse cortex (Das Sharma et al. 2019). c) Volcano plots showing concordantly diminished translation efficiency of FMRP-bound mRNAs (McMahon et al. 2016; Liu et al. 2018) in FMRP-deficient Drosophila oocytes and in mouse cortex. d) Scatter plots showing reduced translation efficiency as a function of protein size for the 200 most significantly affected genes in Fmr1 RNAi Drosophila oocytes or FMR1 KO mouse cortex. Histograms of size distributions for all Drosophila or mouse proteins respectively are shown to the right. e) Scatter plot showing reduced translation efficiency as a function of CLIP score (Sawicka et al. 2019) for the 200 most significantly affected genes in the FMR1 KO mouse cortex.