Fig. 4.

The translation of FMRP targets is limited by initiation rather than elongation rates. a) Ribosome footprints of FMRP targets Poe, osa, and HUWE1 in control and Fmr1 RNAi oocytes. b) Cumulative distribution plots showing nearly identical distributions of ribosome footprints for FMRP targets in wild-type and Fmr1 RNAi oocytes. c) Ribosome footprints of mouse FMRP targets Arid2, HUWE1, and Auts2. f) Cumulative distribution plot showing nearly identical distributions of ribosome footprints of Arid2, HUWE1, and Auts2 in wild-type vs FMRP-deficient tissue. e, f) Plots showing that all mouse FMRP targets as analyzed as in (d) have low K–S scores <0.3.