Table 1. Presentations and key findings of cases 1 and 2.
T: temperature; RR: respiratory rate; BP: blood pressure; HR: heart rate; SpO2: oxygen saturation; CBC: complete blood count; BMP: basic metabolic panel; TR: repetition time; NAAT: nucleic acid amplification test; CSF: cerebrospinal fluid
| Demographic | Case 1 | Case 2 |
| Age (year) | 5 | 8 |
| Race | African American | Caucasian |
| Gender | Male | Female |
| Symptoms | Fever, rash after 10 days: left-sided weakness, dystonia, limping, | Blurry vision, headache, speech difficulty, vomiting, and altered mental status |
| Duration to onset of neurological symptoms | 10 day | 1 day |
| Vitals | T: 36.7°C, RR: 32/min. BP: 91/63mmHg, HR: 84/min, SpO2: 100% on room air (RA), weight: 16.2 kg | T: 36.8°C, HR: 100/min, RR: 28/min, BP: 109/56 mmHg, SpO2: 100% on RA, Weight: 27 kg |
| Lab workup | Normal CBC, BMP | WBC was elevated to 12.7K/ul. Serum glucose 147. Drug screens: negative |
| CSF | WBC: 2, glucose: 58, and protein: 18 | WBC: 85, RBC: 730, protein and glucose levels within normal range |
| Parechovirus NAAT | Positive | Positive |
| Imaging study | MRI imaging: TR hyperintense lesions in the globus pallidus, the right > left. Patchy enhancement in right globus pallidus. Postcontrast enhancement and restricted diffusion in the right cerebral peduncle. | Normal CT scan |