Table 3.

Categorical Progression after MAR Multiple Imputation

		Intention to Treat (ITT)		As-Treated
Outcome	Time Period	Relative Risk (95% CI) APM vs. PT	p-value	Relative Risk (95% CI) APM vs. PT	p-value
Worsening in number of SRs affected by Osteophytes	BL to M18	1.24 (1.02 – 1.50)	0.0309	1.24 (1.01 – 1.53)	0.0446
	M18 to M60	1.21 (0.81 – 1.82)	0.3535	1.19 (0.75 – 1.87)	0.4548
Any SRs with worsening in Osteophyte Score	BL to M18	1.14 (1.00 – 1.32)	0.0572	1.13 (0.96 – 1.32)	0.1354
	M18 to M60	1.28 (1.04 – 1.58)	0.0196	1.16 (0.91 – 1.48)	0.2352
Worsening in number of SRs affected by cartilage surface area damage	BL to M18	1.44 (1.13 – 1.85)	0.0037	1.44 (1.05 – 1.96)	0.0240
	M18 to M60	1.19 (0.69 – 2.05)	0.5195	1.23 (0.73 – 2.09)	0.4345
Any SRs with worsening in cartilage surface area Score	BL to M18	1.35 (1.14 – 1.61)	0.0007	1.28 (1.04 – 1.56)	0.0188
	M18 to M60	1.02 (0.74 – 1.40)	0.9016	0.95 (0.68 – 1.33)	0.7704
Worsening in number of SRs affected by cartilage thickness damage	BL to M18	1.14 (0.88 – 1.49)	0.3251	1.10 (0.81 – 1.49)	0.5442
	M18 to M60	1.26 (0.86 – 1.84)	0.2341	0.95 (0.66 – 1.35)	0.7599
Any SRs with worsening in cartilage thickness Score	BL to M18	1.16 (0.93 – 1.44)	0.2006	1.13 (0.91 – 1.41)	0.2794
	M18 to M60	1.15 (0.85 – 1.57)	0.3657	0.97 (0.74 – 1.28)	0.8495
Worsening in number of SRs affected by any BML	BL to M18	1.32 (0.96 – 1.82)	0.0851	1.09 (0.76 – 1.58)	0.6293
	M18 to M60	1.43 (0.97 – 2.10)	0.0722	1.33 (0.88 – 2.02)	0.1741
Any SRs with worsening in BML Score	BL to M18	1.24 (1.01 – 1.53)	0.0374	1.09 (0.87 – 1.36)	0.4661
	M18 to M60	1.11 (0.92 – 1.35)	0.2804	1.07 (0.87 – 1.32)	0.5041
Worsening in Hoffa-Synovitis	BL to M18	0.85 (0.47 – 1.53)	0.5897	1.56 (0.78 – 3.10)	0.2045
	M18 to M60	1.45 (0.63 – 3.34)	0.3726	1.17 (0.51 – 2.71)	0.7038
Worsening in Effusion-Synovitis	BL to M18	2.62 (1.32 – 5.21)	0.0060	2.09 (0.97 – 4.51)	0.0594
	M18 to M60	0.92 (0.50 – 1.71)	0.7974	0.88 (0.43 – 1.80)	0.7280