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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 May 5;42(8):1060–1076. doi: 10.1161/ATVBAHA.122.317643

Figure 4: Aging dysregulates more processes in the aorta in health compared to TAA.

Figure 4:

Aortic samples were assessed via mass spectrometry. Young (i.e., <60 years of age) and old (i.e., >60 years of age) in the healthy and TAA groups were compared. N = 4 biological specimens / group. A and B: Top 10 gene ontology (GO) biological processes from proteins that were significantly up- (A) and down- (B) regulated in the healthy group comparing aged to young and sorted by adjusted p-value. C and D: Top 10 GO biological processes from proteins that were significantly up- (C) and down- (D) regulated in the TAA group comparing aged to young and sorted by adjusted p-value. GO biological processes within similar categories were color coded the same. Blue encodes metabolic and mitochondrial processes, orange encodes immune and inflammatory processes, yellow encodes hemolysis and coagulation processes, pink encodes cytoskeletal and extracellular matrix processes, cyan encodes posttranslational modifications, and teal encodes golgi-related processes.