Figure 1:

Mechanism of action of the novel antifungals MAT2203, miltefosine, NP339, oteseconazole, ATI-2307 (=T-2307) and VL-2397. For ibrexafungerp, fosmanogepix and rezafungin a corresponding figure has been published before ²⁸. Dotted lines indicate that the exact mechanism of action is still under investigation. Depicted mechanism for miltefosine is based on Wu et al., 2020 ¹²⁷; NP339 is based on Duncan et al., 2021 ¹¹⁷; VL-2397 on Dietl et al., 2019 ¹⁰⁷ Abbreviations: CYP, cytochrome P; SIT1, siderophore iron transporter 1.