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. Author manuscript; available in PMC: 2023 Jan 20.
Published in final edited form as: Nature. 2022 Jul 20;607(7920):769–775. doi: 10.1038/s41586-022-04896-7

Extended Data 1: Interaction of ZBP1 with RNA and ADAR1.

Extended Data 1:

A. Co-precipitation ADAR1 with WT or mutant Zαβ (mZαβ) Flag-tagged ZBP1 (FLAG-ZBP1) after FLAG immunoprecipitation. Β. Immunoprecipitation and IR-CLIP analysis for RNA binding by of WT or mZαβ FLAG-ZBP1. C. Co-precipitation of ADAR1 and FLAG-tagged ZBP1 after UV-crosslinking. These experiments were performed in HEK293T cells.