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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Lancet Oncol. 2022 Jul 7;23(8):1009–1020. doi: 10.1016/S1470-2045(22)00369-2

Table 2.

Efficacy Data by Arm

Arm PFS6 ORR
(measurable
only)
mPFS mOS mPFS
(non-BRCA or
PALB2)
mOS
(non-BRCA or
PALB2)
mPFS
(no DDR
variant)
mOS
(no DDR
variant)
% (95% CI) Mo (95% CI)
Nira/Nivo N = 44 N = 42 N = 44 N = 44 N = 37 N = 37 N = 32 N = 32
Nira/Ipi N = 40 N = 39 N = 40 N = 40 N = 33 N = 33 N = 30 N = 30
Nira/Nivo 20.6 (8.3-32.9)
p=0.0002 vs 44%
7.1 (1.5-19.5) 1.9 (1.4-2.3) 13.2 (8.1-16.7) 1.9 (1.8-1.9) 13.2 (8.1-16.7) 1.8 (1.8-1.9) 13.2 (6.1-20.3)
Nira/Ipi 59.6 (44.3-74.9)
p=0.045 vs 44%
15.4 (5.9-30.5) 8.1 (5.5-10.6) 17.3 (12.8-21.9) 7.6 (4.0-11.1) 17.3 (12.5-22.2) 7.6 (2.8-12.3) 15.0 (4.3-25.7)

Italics indicate lack of overlap between CIs