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. 2022 Aug 1;7:259. doi: 10.1038/s41392-022-01054-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Histological and immunohistochemical staining in four groups of mice. a Representative images of hearts and myocardial cross-sections in four groups of mice: representative heart pictures (scale bar: 2 mm) were shown in the upper panel; Representative H&E staining of myocardial cross-sections (scale bar: 1000 μm) were shown in the lower panel. b Representative Masson’s trichrome staining of myocardial fibers. Masson’s trichrome staining of cardiac short-axis cross sectional areas (scale bar: 1000 μm) were shown in the middle panel. Dotted boxes in the middle panel indicated a local area in the low magnification field (scale bar: 1000 μm), which was enlarged in the high magnification field (scale bar: 50 μm) in the bottom panel. The interstitial fibrosis images were shown in the top panel and the perivascular fibrosis images were shown in the bottom panel. c Representative TUNEL-positive cardiomyocyte staining in mice (scale bar: 20 μm). d Quantitative analysis of heart weight/tibial length (HW/TL) ratio in mice, n = 6. e and f Quantification of the interstitial and perivascular fibrosis area in mice, n = 6. g Quantification of TUNEL-positive cardiomyocytes in mice, n = 6. Data were expressed as mean ± SEM. *P < 0.05, ***P < 0.001 vs. the A17^fl/fl control group; ^#P < 0.05, ^###P < 0.001 vs. the A17^fl/fl DM group.