Table 1.

Demographic, clinical, cognitive, and neuroimaging among male and female PSEN1 mutation carriers and non-carriers

	PSEN1 Mutation Carriers (n=167)		p-valuea	p-valueb	Non-carriers (n=75)		p-valuec
	Males (n=66)	Females (n=101)			Males (n=25)	Females (n=50)
Age	37.7±5.8	35.9±5.1	.04		41.5±6.3	42.2±6.1	.62
Education	8.82±4.16	8.73±4.03	.89		8.32±4.75	8.58±4.24	.81
MMSE	28.80±1.15	28.82±1.53	.932	.670	29.28±0.74	29.16±1.06	.61
Amyloid burden	.88± .14	0.84±0.13	.075	.470	0.64±0.04	.65±.03	.30
Hippocampal Volume × 103	5.78± .53	5.91±0.41	.087	.219	5.81±0.42	5.90±.46	.39
FDG Precuneus	2.41± .15	2.42±0.14	.634	.992	2.48±0.14	2.47±.12	.72
CERAD Word List Learning	19.20±4.50	20.69±3.97	.026	.173	20.80±3.93	21.30±4.05	.61
CERAD Word List Delayed Recall	6.41±2.40	7.21±2.02	.022	.154	7.28±2.17	7.90±1.66	.17
FCSRT Total Recall	41.0±7.60	43.24±5.46	.029	.145	43.84±3.54	44.92±2.93	.20
FCSRT Delay	13.65±3.20	14.51±2.52	.056	.216	14.88±1.67	15.34±.98	.21
Constructional Praxis	9.83±1.22	9.73±1.44	.632	.488	10.12±0.83	10.12±1.15	1.00
MiNT (Naming)	11.67±3.00	11.68±2.28	.974	.704	11.24±3.92	11.80±2.52	.46
Raven Progressive Matrices	9.20±1.88	9.02±1.89	.556	.231	9.20±2.00	9.00±1.73	.66

Note. Abbreviations: FDG, ¹⁸F-fludeoxyglucose (FDG) positron emission tomography; MMSE, Mini-Mental Status Exam; CERAD, Consortium to Establish a Registry for AD; MiNT, Multilingual Naming Test; FCSRT, Free and Cued Selective Reminding Test.

^ap-value as defined by a t-test for males vs females in PSEN1 mutation carriers.

^bp-value as defined by a t-test for males vs females in PSEN1 mutation carriers controlling for age.

^cp-value as defined by a t-test for males vs females in non-carriers.