Table 4.
Regression estimates of the effect of APOE ε4 on markers of pathology, neurodegeneration and cognition
| Outcome Variable | Predictors | Standardized β | p-value |
|---|---|---|---|
| Amyloid Burden | PSEN1 status | −17.574 | .000 |
| Sex | −.957 | .339 | |
| Age | 7.157 | .000 | |
| APOE ε4 | −1.519 | .130 | |
| Sex × APOE ε4^ | −.992 | .322 | |
| FDG Precuneus | Amyloid burden | −3.820 | .000 |
| PSEN1 status | −.097 | .923 | |
| Sex | −.232 | .816 | |
| Age | −.252 | .801 | |
| APOE ε4 | −.012 | .990 | |
| Sex × APOE ε4^ | −.733 | .464 | |
| Hippocampal Volume | Amyloid burden | −1.140 | .255 |
| PSEN1 status | −.260 | .795 | |
| Sex | 1.710 | .088 | |
| Age | −1.098 | .273 | |
| APOE ε4 | −.456 | 0.649 | |
| Sex × APOE ε4^ | .194 | .846 | |
| Word List Delayed Recall | FDG Precuneus | 1.513 | .132 |
| Amyloid burden | −.473 | .637 | |
| PSEN1 status | 3.375 | .001 | |
| Sex | 1.929 | .055 | |
| Age | −6.667 | .000 | |
| APOE ε4 | .662 | .509 | |
| Sex × APOE ε4^ | −1.338 | .182 | |
| Word List Delayed Recall | Hippocampal Volume | 2.514 | .013 |
| Amyloid burden | −.612 | .541 | |
| PSEN1 status | 3.508 | .000 | |
| Sex | 1.600 | .111 | |
| Age | −6.606 | .000 | |
| APOE ε4 | .730 | .466 | |
| Sex × APOE ε4^ | −1.465 | .144 |
Note. Abbreviations: Amyloid burden, Logio mean cortical florbetapir standard uptake value ratios; FDG Precuneus, 18F-fluodeoxyglucose metabolism in the precuneus; Word List Delayed Recall, squared CERAD Word List – Delayed Recall; PSEN1 status, PSEN1 Carriers/Non-carriers. Bold text represents p-value <.05.
^
Subsequent model was run adding the interaction term.