Table 2:
Hazard Ratios for progression to a clinical diagnosis of AD for each predictor variable in bivariate survival analyses.
| Hazard Ratios (95% CI) | Wald X2 | p-value | |
|---|---|---|---|
| Demographics | |||
| Age | 1.12 (1.12–1.13) | 834.84 | <.001 |
| MMSE | .79 (.76–.82) | 185.84 | <.001 |
| Education (yrs) | 1.00 (.98–1.02) | .001 | .97 |
| Sex (male) | 1.00 (.87–1.14) | .003 | .95 |
| Medications | |||
| Anxiolytic | 1.23 (.99–1.53) | 3.58 | .06 |
| Antidepressant | 1.73 (1.48–2.02) | 45.83 | <.001 |
| Antipsychotic | 1.63 (.67–3.98) | 1.15 | .28 |
| Medical Conditions | |||
| Diabetes | 1.25 (1.00–1.55) | 3.91 | .05 |
| Hypercholesterolemia | .80 (.70–.90) | 12.91 | <.001 |
| Hypertension | 1.06 (.94–1.20) | .78 | .38 |
| Heart attack | 1.21 (.65–2.29) | .36 | .55 |
| Atrial Fibrillation | 1.14 (.86–1.51) | .79 | .37 |
| Stroke | 4.53 (2.58–7.93) | 27.86 | <.001 |
| TIA | 1.07 (.58–1.97) | .05 | .82 |
| Health Behaviours | |||
| Smoking (years) | 1.00 (.99–1.00) | .07 | .80 |
| Alcohol abuse (present versus absence) | 1.43 (.75–2.74) | 1.15 | .28 |
| Other Risk Factors | |||
| APOE4 allele (presence versus not) | 3.10 (2.74–3.49) | 336.54 | <.001 |