Table 1.

The role of complement system in the kidney under different metabolic disorders.

Metabolic disorders	Components of complement system	Renal damage
Diabetic kidney disease	The lectin pathway, CD59	Albuminuria, declined eGFR, glomerular hypertrophy, renal fibrosis
Hypertensive kidney disease	The alternative pathway	Glomerular cell proliferation, cell necrosis, glomerulosclerosis, phenotypic transformation of MCs
Obesity-related nephropathy	C3a, C5a, properdin	Albuminuria, MCs proliferation, macrophage accumulation, and polarization
Hyperuricemia-induced kidney disease	The classic pathway The alternative pathway	Albuminuria and renal fibrosis