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. 2022 Jul 18;13:927817. doi: 10.3389/fpsyt.2022.927817

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Copyright © 2022 Zhang, Guo, Li, Wang, Yang, Yang, Cui, Zhou, Chen, Yu, Peng and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristic lipid species between MDD and BPD. (A) Scatter plot of OPLS-DA model and (B) validation model of permutation test, (C) volcano map reveals the increased (red dots) and decreased (blue dots) lipid species between the MDD and BPD, (D) random forest model and 10-fold cross-validation showed that the lipids with the top 13 importance had the lowest model error rate, (E) ROC analysis for the combinational lipids, (F) correlation between clinical parameters and levels of 13 lipid species. *P < 0.05; **P < 0.01, ***P < 0.001.