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. 2022 Jul 18;9:922347. doi: 10.3389/fmed.2022.922347

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Copyright © 2022 Wang, Fang, Zhang, Li and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The analysis of iPSC-derived CMs indicated an ARVC-associated phenotype. (A) Histogram of KEGG signaling pathway classification. (B) KEGG enrichment analysis of the adherent signaling pathway. (C) Western blot results showed the protein expressions of LAMA2, CTCF, Integrin-β1, β-Dystroglycan, FABP4, and Adiponectin in myocardium cells of the control group and the ARVC group, with GAPDH as internal reference. (D) Histogram shows the protein expression differences of LAMA2, CTCF, Integrin-β1, β-Dystroglycan, FABP4, and Adiponectin between the control group and the ARVC group (N.S. The difference is meaningless; *p < 0.05; **p < 0.01; ***p < 0.001).