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. 2022 Jul 18;13:838374. doi: 10.3389/fimmu.2022.838374

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Copyright © 2022 Zhang, Yao, Wu, Zhou, Zhao, He and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic alteration landscape of each TME cluster. (A) The log10TMB of each cluster, gene-level CNV mutational signature, waterfall chart of significant (>5%) and differently (Fisher’s exact test p < 0.1) mutated genes, and heatmap of gene copy number variation were shown from the top to the bottom panels. Patients were ordered by the combined contribution of APOBEC-related mutational signatures (SBS2 + SBS13) with each cluster. (B) GISTIC copy number variation analysis. The amplifications and deletions of chromosomal regions were colored red and blue, respectively (FDR cutoff: 0.01).