Table 1.
Outcome of regulatory studies of genotoxicity of CTD, IMZ and THI.
| Study type endpoint | Clothianidin | Imazalil | Thiacloprid |
|---|---|---|---|
| Ames test | Negative (5/6 studies) | Negative in all studies | Negative in all studies |
| Point mutation in mammalian cells | Negative in all studies | Negative in all studies | Negative in all studies |
| Clastogenicity in vitro | Positive (2/3 studies) | Negative in all studies | Negative in all studies |
| Genotoxicity in vivo | Negative 6/6 studies | Negative in all studies | Negative in all studies |
| Overall conclusion | WoE not genotoxic in vivo | Not genotoxic | Not genotoxic |
| Source | FAO/WHO JMPR 2011 a | FAO/WHO JMPR 2000 b | FAO/WHO JMPR 2006 c |
Footnotes:
a
, https://inchem.org/documents/jmpr/jmpmono/v2010pr01.pdf.
b
, https://inchem.org/documents/jmpr/jmpmono/v00pr08.htm#_00082240.