TABLE 3.
Multiple alignment in region of known Echr mutations
| Sequence or species | Protein | Amino acid sequenceb |
|---|---|---|
| Consensusa | Phe Leu Thr Leu Ser Leu Arg Asp | |
| C. neoformans | Fks1p | Phe Leu Thr Leu Ser Phe Arg Asp |
| S. cerevisiae | Fks1p | Phe Leu Val Leu Ser Leu Arg Asp |
| S. cerevisiae | Fks2p | Phe Leu Ile Leu Ser Leu Arg Asp |
| C. albicans | CaFksp | Phe Leu Thr Leu Ser Leu Arg Asp |
| A. fumigatus | AfFksp | Phe Leu Thr Leu Ser Phe Arg Asp |
| A. nidulans | AnFksp | Phe Leu Thr Leu Ser Ile Arg Asp |
| S. cerevisiae | Fks1-2p | Ile Leu Val Leu Ser Leu Arg Asp |
| S. cerevisiae | Fks1-3p | Phe Leu Val Leu Ser Leu Arg Tyr |
| S. cerevisiae | Fks2-1p | Phe Leu Lys Leu Ser Leu Arg Asp |
a
The consensus represents the most prevalent residue from the known wild-type sequences.
b
Wild-type deviations from the consensus sequence are shown in bold type. The sequences of three known echinocandin-resistant mutations are listed at the bottom with the substituted residues underlined.