Table 1.
Age-adjusted incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) among US adults by age group and sex during 2002-2006 and 2014-2018.
| Incidence (per 1,000,000 person-years) | Rate ratio 2014-2018/2002-2006 | ||
|---|---|---|---|
| 2002-2006 | 2014-2018 | RR (95% CI) | |
| Male | |||
| 20-44 years old | |||
| All | 12.8 (12.4-13.3) | 11.4 (10.9-11.8) | 0.86 (0.78-0.95) |
| Race/Ethnicity | |||
| Hispanic | 5.4 (4.7-6.2) | 5.0 (4.4-5.7) | 0.93 (0.77-1.14) |
| Non-Hispanic White | 14.8 (14.3-15.4) | 14.6 (13.9-15.3) | 0.98 (0.93-1.04) |
| Non-Hispanic Black | 12.8 (11.5-14.1) | 10.1 (9.0-11.3) | 0.79 (0.67-0.92) |
| Asian/Pacific Islander | 4.2 (3.1-5.5) | 3.5 (2.7-4.6) | 0.85 (0.57-1.26) |
| Region | |||
| Northeast | 11.2 (10.2-12.2) | 3.4 (2.9-3.9) | 0.95 (0.83-1.08) |
| Midwest | 13.4 (12.5-14.4) | 3.5 (3.0-4.0) | 1.02 (0.92-1.14) |
| South | 15.5 (14.7-16.3) | 4.3 (3.9-4.8) | 0.81 (0.74-0.87) |
| West | 9.5 (8.7-10.3) | 2.6 (2.2-3.0) | 0.87 (0.76-0.98) |
| 45-64 years old | |||
| All | 170.8 (168.8-172.7) | 220.3 (218.3-222.3) | 1.15 (1.12-1.19) |
| Race/Ethnicity | |||
| Hispanic | 92.6 (87.7-97.7) | 92.8 (89.2-96.5) | 1.00 (0.94-1.07) |
| Non-Hispanic White | 182.7 (180.4-185.0) | 266.6 (263.9-269.2) | 1.46 (1.44-1.48) |
| Non-Hispanic Black | 198.8 (192.2-205.6) | 152.7 (147.8-157.6) | 0.77 (0.73-0.80) |
| Asian/Pacific Islander | 39.0 (34.4-43.9) | 47.8 (43.8-52.1) | 1.23 (1.06-1.43) |
| Region | |||
| Northeast | 161.6 (157.3-166.0) | 33.0 (31.2-35.0) | 1.29 (1.25-1.34) |
| Midwest | 164.6 (160.6-168.6) | 34.6 (32.8-36.4) | 1.43 (1.38-1.47) |
| South | 193.1 (189.7-196.6) | 37.7 (36.3-39.2) | 1.27 (1.24-1.29) |
| West | 149.2 (145.3-153.1) | 27.7 (26.1-29.4) | 1.19 (1.15-1.23) |
| 65+ years old | |||
| All | 174.6 (171.7-177.6) | 284.4 (281.2-287.6) | 1.07 (1.04-1.11) |
| Race/Ethnicity | |||
| Hispanic | 149.4 (138.1-161.4) | 187.4 (178.2-197.1) | 1.25 (1.14-1.38) |
| Non-Hispanic White | 175.7 (172.5-179.0) | 310.7 (307.0-314.4) | 1.77 (1.73-1.81) |
| Non-Hispanic Black | 223.1 (211.2-235.5) | 227.2 (217.3-237.5) | 1.02 (0.95-1.09) |
| Asian/Pacific Islander | 72.7 (61.9-84.8) | 83.0 (75.0-91.7) | 1.14 (0.95-1.38) |
| Region | |||
| Northeast | 170.8 (164.3-177.5) | 53.5 (50.4-56.7) | 1.56 (1.49-1.64) |
| Midwest | 159.6 (153.8-165.6) | 53.9 (51.0-57.0) | 1.69 (1.62-1.77) |
| South | 192.7 (187.6-197.9) | 56.3 (53.9-58.7) | 1.60 (1.55-1.65) |
| West | 163.5 (157.4-169.9) | 56.0 (52.8-59.3) | 1.66 (1.58-1.73) |
| Female | |||
| 20-44 years old | |||
| All | 3.6 (3.3-3.8) | 3.0 (2.8-3.3) | 0.89 (0.84-0.93) |
| Race/Ethnicity | |||
| Hispanic | 1.7 (1.3-2.2) | 1.9 (1.5-2.3) | 1.14 (0.81-1.61) |
| Non-Hispanic White | 4.0 (3.7-4.3) | 3.8 (3.4-4.1) | 0.95 (0.85-1.07) |
| Non-Hispanic Black | 4.0 (3.3-4.7) | 2.4 (1.9-3.0) | 0.60 (0.45-0.80) |
| Asian/Pacific Islander | 2.2 (1.5-3.2) | 1.5 (1.0-2.1) | 0.66 (0.38-1.14) |
| Region | |||
| Northeast | 10.6 (9.6-11.7) | 3.3 (2.7-3.9) | 0.96 (0.76-1.22) |
| Midwest | 13.7 (12.6-14.8) | 3.5 (3.0-4.0) | 1.00 (0.81-1.23) |
| South | 12.5 (11.8-13.3) | 3.4 (3.0-3.8) | 0.79 (0.68-0.92) |
| West | 8.2 (7.5-9.0) | 2.0 (1.6-2.4) | 0.77 (0.60-0.99) |
| 45-64 years old | |||
| All | 33.9 (33.1-34.7) | 39.1 (38.3-39.9) | 1.29 (1.27-1.31) |
| Race/Ethnicity | |||
| Hispanic | 14.7 (12.8-16.7) | 18.0 (16.5-19.7) | 1.23 (1.05-1.44) |
| Non-Hispanic White | 36.4 (35.4-37.4) | 46.2 (45.1-47.3) | 1.27 (1.23-1.32) |
| Non-Hispanic Black | 41.0 (38.3-43.8) | 33.9 (31.8-36.1) | 0.83 (0.75-0.91) |
| Asian/Pacific Islander | 9.1 (7.1-11.5) | 10.1 (8.4-11.9) | 1.11 (0.82-1.50) |
| Region | |||
| Northeast | 208.5 (204.0-213.1) | 37.9 (36.0-39.8) | 1.15 (1.06-1.24) |
| Midwest | 234.7 (230.3-239.1) | 41.2 (39.4-43.1) | 1.19 (1.11-1.28) |
| South | 244.4 (241.0-247.8) | 43.8 (42.4-45.2) | 1.16 (1.10-1.22) |
| West | 177.2 (173.5-180.9) | 30.2 (28.7-31.8) | 1.09 (1.01-1.18) |
| 65+ years old | |||
| All | 55.1 (53.6-56.5) | 59.0 (57.7-60.4) | 1.63 (1.60-1.66) |
| Race/Ethnicity | |||
| Hispanic | 31.5 (27.2-36.3) | 33.5 (30.2-37.1) | 1.06 (0.89-1.27) |
| Non-Hispanic White | 58.7 (57.1-60.4) | 66.3 (64.7-67.9) | 1.13 (1.09-1.17) |
| Non-Hispanic Black | 50.1 (45.6-54.8) | 39.7 (36.4-43.3) | 0.79 (0.70-0.90) |
| Asian/Pacific Islander | 20.4 (15.7-26.2) | 23.0 (19.3-27.2) | 1.13 (0.83-1.55) |
| Region | |||
| Northeast | 267.0 (259.9-274.4) | 61.5 (58.5-64.7) | 1.15 (1.06-1.24) |
| Midwest | 270.1 (263.5-276.8) | 59.9 (57.1-62.8) | 1.11 (1.03-1.20) |
| South | 308.7 (303.4-314.1) | 61.4 (59.3-63.6) | 1.09 (1.03-1.15) |
| West | 271.0 (264.5-277.6) | 52.0 (49.4-54.7) | 0.93 (0.86-1.00) |