Table 4. Univariate and multivariate cox regression analysis for primary outcome .
| Univariate analysis | Multivariate analysis | |||||
| HR | 95% CI | p-value | HR* | 95% CI | p -value | |
| PTMC | 1.71 | 1.04, 2.79 | 0.034 | 1.94 | 1.14, 3.32 | 0.015 |
| Age | 1.04 | 1.02, 1.06 | <0.001 | 1.03 | 1.01, 1.06 | 0.009 |
| Female | 0.94 | 0.55, 1.60 | 0.815 | |||
| Atrial fibrillation | 1.42 | 0.86, 2.32 | 0.168 | |||
| Comorbidity | ||||||
| Type 2 diabetes mellitus | 3.64 | 2.18, 6.09 | <0.001 | 2.29 | 1.00, 5.25 | 0.050 |
| Hypertension | 2.19 | 1.32, 3.65 | 0.003 | 0.98 | 0.45, 2.16 | 0.960 |
| Dyslipidemia | 1.51 | 0.76, 3.03 | 0.244 | |||
| Chronic kidney disease, (GFR < 60 ml/min/1.73 m2) | 2.72 | 0.85, 8.67 | 0.091 | 1.80 | 0.54, 6.03 | 0.343 |
| Indication | ||||||
| Dyspnea | 0.70 | 0.45, 1.09 | 0.113 | 0.76 | 0.46, 1.26 | 0.287 |
| Heart failure | 1.37 | 0.88, 2.13 | 0.170 | |||
| Stroke and systemic embolism | 0.98 | 0.50, 1.90 | 0.949 | |||
| New-onset atrial fibrillation | 1.04 | 0.58, 1.85 | 0.905 | |||
| SPAP > 50 mmHg | 3.15 | 1.13, 8.76 | 0.028 | 2.99 | 1.01, 8.84 | 0.047 |
| Planned pregnancy or major surgery | 0.75 | 0.10, 5.44 | 0.778 | |||
| Preprocedural Echocardiographic data | ||||||
| Wilkins’ score | 1.07 | 0.95, 1.21 | 0.270 | |||
| Wilkins’ score ≥ 8, (%) | 1.16 | 0.66, 2.05 | 0.599 | |||
| MVA by planimetry, cm2 | 0.57 | 0.24, 1.35 | 0.199 | |||
| Mean PG, mmHg | 0.96 | 0.92, 1.01 | 0.107 | 1.00 | 0.95, 1.05 | 0.938 |
| RVSP, mmHg | 1.01 | 0.99, 1.02 | 0.249 | |||
| Mean PAP, mmHg | 1.01 | 0.98, 1.03 | 0.559 | |||
Abbreviations: GFR , Glomerular filtration rate; MVA , Mitral valve area; PAP , Pulmonary arterial pressure; PG , pressure gradient; PTMC , Percutaneous mitral commissurotomy; RVSP , Right ventricular systolic pressure; SPAP , Systolic pulmonary arterial pressure.
* Adjusted with factors which p-value in univariate analysis < 0.15