TABLE 1.
Demographics for COPD subjects and ex-smoking and healthy non-smoking (HNS) controls
| Monocyte-derived macrophages | Lung macrophages | |||||
| HNS | COPD | p-value | Ex-smoker | COPD | p-value | |
| Subjects n | 10 | 10 | 4 | 4 | ||
| Age years | 32 (23–56) | 67 (53–73) | <0.0001 | 74 (71–83) | 67 (59–78) | 0.49 |
| Sex: M/F | 6/4 | 5/5 | 0/4 | 2/2 | ||
| FEV1 L | 3.4±0.6 | 1.5±0.8 | <0.0001 | 2.3±1.1 | 1.7±0.4 | 0.30 |
| FEV1 % predicted | 99±11 | 53±21 | <0.0001 | 82±20 | 77±10 | 0.60 |
| FVC L | 4.5±1.1 | 3.3±1.1 | 0.03 | 3.3±1.5 | 2.6±0.6 | 0.4 |
| FEV1/FVC ratio (%) | 76±7 | 37±16 | <0.0001 | 77±6 | 65±2 | 0.1 |
| Current smokers % | NA | 20 | 0 | 50 | ||
| Pack-years | NA | 39±11 | 12±14 | 50±26 | 0.2 | |
| ICS usage % | NA | 60 | NA | 25 | ||
Data presented as median (range) or mean±sd as appropriate, unless indicated otherwise. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; ICS: inhaled corticosteroids.