TABLE 1.

Functional annotation of FTO variants.

Variants	MutPred2 score	Molecular consequences	Probability	P-value
R96M	0.921	Altered Ordered interface	0.37	3.0e-03
		Loss of Relative solvent accessibility	0.33	4.0e-03
		Altered DNA binding	0.32	1.7e-03
		Gain of Loop	0.29	7.0e-03
		Loss of Allosteric site at R96	0.26	0.01
		Altered Transmembrane protein	0.23	1.9e-03
		Altered Metal binding	0.20	0.04
Y108A	0.926	Altered Ordered interface	0.35	2.3e-03
		Altered Transmembrane protein	0.26	1.2e-03
		Loss of Acetylation at K107	0.21	0.04
		Loss of Allosteric site at Y106	0.20	0.04
		Altered Stability	0.20	0.01
		Altered DNA binding	0.16	0.16
		Gain of Catalytic site at R112	0.10	0.04
F114D	0.943	Loss of Strand	0.27	0.03
		Gain of Relative solvent accessibility	0.26	0.03
		Altered Transmembrane protein	0.25	1.3e-03
		Altered Ordered interface	0.24	0.04
		Altered DNA binding	0.22	0.01
		Gain of Allosteric site at R112	0.20	0.04
		Altered Stability	0.13	0.03
E234P	0.598	Altered Metal binding	0.52	3.6e-03
		Altered Ordered interface	0.24	0.05
		Gain of Allosteric site at W230	0.20	0.04
R316Q	0.237	–	–	–
R322Q	0.504	–	–	–
C392D	0.727	Altered Ordered interface	0.25	0.02
		Altered Disordered interface	0.19	0.04
		Altered Transmembrane protein	0.13	0.02