Table 4.
The Mean AUC0-t and Target Index of Different Formulations of NPs in Different Organs of Mice (Mean ± SD, n=8)
| AUC0-t (ngh/g) | GEM(Free GEM/CUR) | GEM(HSA-GEM/CUR NPs) | GEM(RGD-HSA-GEM/CUR NPs) | CUR(Free GEM/CUR) | CUR(HSA-GEM/CUR NPs) | CUR(RGD-HSA-GEM/CUR NPs) |
|---|---|---|---|---|---|---|
| Tumor | 4096.5±327.2 | 7096.8±540.9 | 9637.0±656.3 | 6055.0±398.5 | 6617.0±412.3 | 8832.8±433.6 |
| Heart | 5364.8±298.3 | 4188.3±329.7 | 3791.3±327.5 | 5379.8±376.3 | 5662.5±309.2 | 4032.8±309.2 |
| Liver | 5201.5±343.2 | 2871.6±293.4 | 2653.9±253.2 | 5629.4±329.1 | 5410.7±314.3 | 2432.6±298.3 |
| Spleen | 5688.8±432.1 | 4845.5±378.5 | 5239.5±367.5 | 6340.8±436.4 | 5775.3±331.3 | 5172.3±287.5 |
| Lung | 5901.8±309.2 | 5445.5±438.6 | 5739.0±219.4 | 7564.5±459.4 | 6376.5±378.4 | 6583.0±423.5 |
| Kidney | 5624.0±312.5 | 6141.3±548.7 | 3487.5±328.1 | 4995.5±321.4 | 5305.5±298.7 | 2673.5±278.3 |
| Plasma | 4351.3±298.3 | 5609.0±438.6 | 3741.3±287.5 | 4029.0±309.2 | 5279.0±310.2 | 4901.3±309.2 |
| TI(Tumor/Heart) | 0.76 | 1.69 | 2.54ab | 1.13 | 1.17 | 2.19cd |
| TI(Tumor/Liver) | 0.79 | 2.47 | 3.63ab | 1.08 | 1.22 | 3.63cd |
| TI(Tumor/Spleen) | 0.72 | 1.46 | 1.84a | 0.95 | 1.15 | 1.71cd |
| TI(Tumor/Lung) | 0.69 | 1.30 | 1.68a | 0.80 | 1.04 | 1.34c |
| TI(Tumor/Kidney) | 0.73 | 1.16 | 2.76ab | 1.21 | 1.25 | 3.30cd |
| TI(Tumor/Plasma) | 0.94 | 1.27 | 2.58ab | 1.50 | 1.25 | 1.80d |
Notes: ap<0.05: GEM(RGD-HSA-GEM/CUR NPs) vs GEM(free GEM/CUR); bp<0.05: GEM(RGD-HSA-GEM/CUR NPs) vs GEM(HSA-GEM/CUR NPs); cp<0.05: CUR(RGD-HSA-GEM/CUR NPs) vs CUR(free GEM/CUR); dp<0.05: CUR(RGD-HSA-GEM/CUR NPs) vs CUR(HSA-GEM/CUR NPs).