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. 2022 Jul 26;17:3217–3237. doi: 10.2147/IJN.S364264

Figure 4.

Figure 4

USI, PAI and MRI in vitro and in vivo experiments. (A) In vitro US images and echo intensity value of FCNPIFE. (B) US images of tumors in Y79 tumor-bearing mice with injections of FCNPIFE, FCNIFE, and CNPI before /after 808nm laser irradiation. (C) Corresponding echo intensities within tumor regions before/after 808nm laser irradiation (n=3, **p < 0.01, ***p < 0.001). (D) In vitro PA images and PA value of FCNPIFE. (E) PA images of tumors in Y79 tumor-bearing mice after injections of FCNPIFE, CNPI and FCNPFE at different time points. (F) Corresponding PA intensities within tumor regions at different time points (n=3, ****p < 0.0001). (G) In vitro MRI and the transverse relaxivity (r2) of FCNPIFE. (H) T2 images of tumors in Y79 tumor-bearing mice after injections of FCNPIFE, FCNPI at different time points. (I) Corresponding signal intensities within tumor regions at different time points (n=3, *p < 0.05, ****p < 0.0001).