Table 2.

TEAEs, over 48 weeks

	CLS-TA (N=28)	Control (N=5)	Total (N=33)
	n (%) of n subjects events	n (%) of n subjects events	n (%) of n subjects events
Any TEAE	19 (67.9) 60	3 (60.0) 8	22 (66.7) 68
Any TEAE in the Study eye	18 (64.3) 30	3 (60.0) 5	21 (63.6) 35
Any non-ocular TEAE	4 (14.3) 18	1 (20.0) 2	5 (15.2) 20
Any SAE	1 (3.6) 10	0	1 (3.0) 10
Any SAE in the Study eye	0	0	0
Any non-ocular SAE	1 (3.6) 10	0	1 (3.0%) 10
Deaths	0	0	0
Any on-study TEAE	16 (57.1) 37	3 (60.0) 6	19 (57.6) 43
Any on-study TEAE in the Study eye	16 (57.1) 20	3 (60.0) 4	19 (57.6) 24
Any on-study non-ocular TEAE	2 (7.1) 11	1 (20.0) 2	3 (9.1) 13
	n (%) of Subjects	n (%) of Subjects	n (%) of Subjects
Any IOP-related event	4 (14.3)	0	4 (12.1)
IOP increase ≥10 mm Hg	4 (14.3)	0	4 (12.1)
IOP ≥25 mm Hg	2 (7.1)	0	2 (6.1)
IOP ≥30 mm Hg	1 (3.6)	0	1 (3.0)
IOP ≥35 mm Hg	0	0	0
Use of IOP-lowering medication at crossover visit*	2 (7.1)	0	2 (6.1)
Use of any additional IOP-lowering medication†	1 (3.6)	0	1 (3.0)
Surgery for elevated IOP	0	0	0
Any cataract	7 (25.0)	1 (20.0)	8 (24.2)
Surgery for cataract	2 (7.1)	0	2 (6.1)

*Includes those medications that started during PEACHTREE and continued into MAGNOLIA.

†Includes those medications that started during MAGNOLIA.

IOP, intraocular pressure; SAE, serious adverse event; TEAEs, treatment-emergent adverse events.