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Biogenesis and circRNA action mechanisms. There are three types of circRNAs. EcRNAs can be transported into cytosol and account for the majority of circRNAs, while EIciRNAs and ciRNAs are confined to the nucleus. EcRNAs can act as miRNA/RBP sponges (A,B) and protein translation templates (C). EIciRNAs and ciRNAs can function by regulating parental gene transcription (D).
