TABLE 1.
CircRNAs with MI.
| CircRNAs | Source | Target | Action mechamism | Regulation | References |
|---|---|---|---|---|---|
| circRNAs that aggravate the syptoms caused by MI | |||||
| circNfix | Mouse heart, CM | miR-214 | miR-214-Gsk3β | Suppressing cardiac regeneration and functional recovery | Huang et al. (2019) |
| circPostn | MI patients, CM mouse heart | miR-96-5p | miR-96-5p-BNIP3 | Aggravating myocardial injury and cardiac remodeling | Cheng et al. (2020) |
| circPAN3 | Rat heart | miR-221 | miR-221-FoxO3-ATG7 | Promoting cardiac fibrosis induced by MI | Li et al. (2020) |
| circ_0060745 | Mouse heart | --- | NF-κB | Promoting CM apoptosis and inflammation, increasing infarct size | Zhai et al. (2020) |
| circFASTKD1 | HCMEC | miR-106a | miR-106a-LATS1/2-YAP | Suppressing cardiac function and cardiac repairment | Gao et al. (2021) |
| circHIPK3 | Mouse heart, CM | miR-93-5p | miR-93-5p-Rac1-PI3K/Akt< | Enhancing cardiac dysfunction | Wu et al. (2021) |
| circRNA 010567 | CM | miR-141 | miR-141-DAPK1 | Deteriorating the CM injury | Zhao et al. (2021c) |
| Rat heart | TGF-β1 and Smad3 | TGF-β1 and Smad3 | Promoting cardiac fibrosis | Bai et al. (2020) | |
| circROBO2 | Mouse heart, CM | miR-1184 | miR-1184-TRADD | Promoting myocardial apoptosis | Chen et al. (2021) |
| MFACR | MI patients, CM, mouse heart | miR-125b | miR-125b | Promoting the apoptosis of CMs | Wang et al. (2021b) |
| circ-NNT | MI patients, CM | miR-33a-5p | miR-33a-5p-USP46 | Promoting pyroptosis and aggravate myocardial I/R injury | Ye et al. (2021) |
| circRNAs that attenuate the symptoms caused by MI | |||||
| circFndc3b | Mouse heart, MCEC, HUVEC | FUS | FUS- VEGFA | Attenuating apoptosis, improving the functions of left ventricular, and promoting neovascularization | Garikipati et al. (2019) |
| circ-Ttc3 | Rat heart, CM | miR-15b | miR-15b-Arl2 | Inhibiting CM apoptosis and cardiac dysfunction | Cai et al. (2019) |
| circCDYL | Mouse heart, CM | miR-4793-5p | miR-4793-5p-APP | Promoting CM proliferation, cardiac regeneration and repairment | Zhang et al. (2020d) |
| circHIPK3 | Mouse heart, CM, HCAEC | miR-133a | miR-133a- CTGF | Promoting myocardial regeneration and improving myocardial function | Zhang et al. (2020d) |
| CMs, cardiac endothelial cell | miR-29 | miR-29-VEGFA | Improving cardiac function and suppressing cardiac fibrosis | Wang et al. (2020) | |
| circMACF1 | Mouse heart, CM | miR-500b-5p | miR-500b-5p -EMP1 | Attenuating AMI symptoms | Zhao et al. (2021a) |
| circSNRK | Rat heart, CM | miR-103-3p | miR-103-3p-SNRK-GSK3β | Promoting angiogenesis and improving cardiac functions | Zhu et al. (2021) |
| circ_0001206 | CM | miR-665 | miR-665-CRKL | Alleviating H/R-induced CM injury | Wang et al. (2022) |
| circFoxo3 | Rat heart, CM | KAT7 | KAT7 -HMGB1 | Ameliorating cardiac dysfunction and attenuating autophagy | Sun et al. (2021) |