Table 4.
Univariate and multivariate analysis of prognostic factors in all patients.
| No. patients (%) | Overall survival | ||
|---|---|---|---|
| Univariate analysis: P | Multivariate analysis: P | ||
| Age (<60 years old, %) | 35 (76.1) | 0.041 | 0.297 |
| Gender (males,%) | 36 (78.2) | 0.403 | – |
| Heart-related risk factors (yes, %) | 25 (54.3) | 0.094 | 0.127 |
| Clinical stage (IV, %) | 31 (67.4) | 0.831 | – |
| Previous treatment, (yes, %) | 28 (60.9) | 0.247 | – |
| Immunotherapy, (combination, %) | 31 (67.4) | 0.785 | – |
| Symptoms of immune-related myocarditis, (yes, %) | 40 (87.0) | 0.104 | 0.394 |
| Arrhythmia, (yes, %) | 24 (52.2) | 0.577 | – |
| Heart failure grade (Grade 3-4,%) | 32 (69.6) | 0.003 | 0.011 |
| Myocarditis grade (Grade 3-4,%) | 32 (69.6) | 0.003 | * |
| Multi-organ irAEs, (yes, %) | 30 (65.2) | 0.008 | 0.29 |
| Severe myocarditis, (yes, %) | 32 (69.6) | 0.003 | 0.561 |
| Initial corticosteroid therapy (high dose) | 16 (37.2) | 0.779 | – |
*Grade of myocarditis are linearly subordinate to the grade of heart failure.