Representative (A) coronal and (B) sagittal
gray-scale CT scans, disease probability maps (DPMs), Jacobian maps, and
anisotropic deformation index (ADI) images from noncontrast CT scans in
patients in the Severe Asthma Research Program III cohort according to
cluster. For DPMs, green voxels represent normal lung tissue, yellow
voxels represent functional air trapping, and red voxels represent
hyperinflation. For Jacobian and ADI maps, voxels are represented on a
gradient from green to yellow to red. For Jacobian maps, green voxels
represent Jacobian values greater than or equal to 2.5, yellow voxels
represent a Jacobian value of 1.75, and red voxels represent Jacobian
values less than or equal to 1.0. For ADI maps, green voxels represent
ADI values greater than or equal to 1.0, yellow voxels represent an ADI
of 0.5, and red voxels represent an ADI of 0. fSAD = functional small
airway disease.