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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Surg Oncol. 2022 Apr 27;126(3):502–512. doi: 10.1002/jso.26906

Table 1. Demographic, pre-operative, and clinicopathologic characteristics by treatment group.

SF, surgery first; SMNT, single modality neoadjuvant therapy; TNT, total neoadjuvant therapy; BMI, body mass index.

Overall cohort (N=358) SF (N=168) SMNT (N=111) TNT (N=79)
N (%) N (%) N (%) N (%) p-value
Gender
 Female 174 (48.6) 85 (50.6) 56 (50.5) 33 (41.8) 0.40
 Male 184 (51.4) 83 (49.4) 55 (49.5) 46 (58.2)
Race
 White 329 (91.9) 161 (95.8) 100 (90.1) 68 (86.1) 0.053
 Black 18 (5.0) 4 (2.4) 6 (5.4) 8 (10.1)
 Other 11 (3.1) 3 (1.8) 5 (4.5) 3 (3.8)
Age at diagnosis, years
 Median [IQR] * 68 [61, 75] 70 [61.5, 76] 68 [61, 75] 67 [59, 73] 0.079
ECOG
 0 262 (78.2) 125 (82.2) 82 (78.1) 55 (70.5) 0.32
 1 67 (20.0) 25 (16.5) 21 (20.0) 21 (26.9)
 2 6 (1.8) 2 (1.3) 2 (1.9) 2 (2.6)
 Missing 23 16 6 1
Hypertension
 Yes 201 (56.8) 89 (53.0) 62 (57.9) 50 (63.3) 0.31
 No 153 (43.2) 79 (47.0) 45 (42.1) 29 (36.7)
 Missing 4 0 4 0
Smoker
 Yes 146 (41.4) 62 (36.9) 50 (47.2) 34 (43.0) 0.23
 No 207 (58.6) 106 (63.1) 56 (52.8) 45 (57.0)
 Missing 5 0 5 0
Diabetes Mellitus
 Yes 123 (34.8) 62 (36.9) 36 (33.6) 25 (31.6) 0.70
 No 231 (65.2) 106 (63.1) 71 (66.4) 54 (68.4)
 Missing 4 0 4 0
Coronary.Artery Disease
 Yes 109 (30.8) 52 (31.0) 23 (21.5) 34 (43.0) 0.007
 No 245 (69.2) 116 (69.0) 84 (78.5) 45 (57.0)
 Missing 4 0 4 0
Hyperlipidemia
 Yes 110 (33.5) 41 (26.3) 32 (32.7) 37 (50.0) 0.002
 No 218 (66.5) 115 (73.7) 66 (67.4) 37 (50.0)
 Missing 30 12 13 5
BMI ≥ 25
 Yes 188 (66.2) 92 (71.3) 44 (55.7) 52 (68.4) 0.065
 No 96 (33.8) 37 (28.7) 35 (44.3) 24 (31.6)
 Missing 74 39 32 3
NCCN Resectability Classification
 Resectable 155 (46.8) 121 (79.1) 22 (21.6) 12 (15.8) <0.001
 Borderline 144 (43.5) 29 (19.0) 61 (59.8) 54 (71.1)
 Locally advanced 32 (9.7) 3 (2.0) 19 (18.6) 10 (13.2)
 Missing 27 15 9 3
Clinical Stage
 0 5 (1.5) 5 (3.4) 0 (0.0) 0 (0.0) <0.001
 IA 40 (12.4) 32 (21.6) 5 (5.0) 3 (4.0)
 IB 133 (41.1) 66 (44.6) 39 (38.6) 28 (37.3)
 IIA 31 (9.6) 13 (8.8) 14 (13.9) 4 (5.3)
 IIB 59 (18.2) 25 (16.9) 19 (18.8) 15 (20.0)
 III 56 (17.3) 7 (4.7) 24 (23.8) 25 (33.3)
 Missing 34 20 10 4
Initial CA19–9
 N, median 309190 151194 82194 76188 0.93
 IQR * [50.1, 672] [61.9, 545] [52.1, 707] [33, 1062.5]
Post Neoadjuvant CA 19–9
 N, median 7039.9 7537 0.35
 IQR * [11, 178] [12.5, 68]
*

Interquartile range given as [25th percentile,75th percentile]