TABLE 2.
Comparing the differences between different organoid construction biomaterials.
| Sources | Biomaterial | Existing research | |
|---|---|---|---|
| MATRIGEL | Natural | EHS tumor tissue | widely used for studies on cell differentiation, angiogenesis, and tumor growth |
| MATRIGEL-FREE | Natural | Alginate | supported differentiation and maturation of the organoids |
| Collagen gels | inducing fibroblast differentiation during matrix remodeling | ||
| Hyaluronic Acid (HA) | Improved cell-cell and cell-ECM interactions | ||
| Silk | High stromal cell infiltration in the silk scaffolds | ||
| Synthetic | PEG (Poly ethylene Glycol) | Improved growth and expansion of the organoids | |
| PLGA (Poly Lactic Glycolic Acid) | Improved wound healing | ||
| PCL (Poly Caprolactone) | Improved tumoroid formation with porous PCL substrate | ||
| Hybrid hydrogels | Low immunogenicity |
EHS, Engelbreth-Holm-Swarm; ECM, extracellular matrix.