Table 3.
Association between alcohol consumption and risk of microscopic colitis according to selected strata
| Alcohol intake (g) | Cases | Person-years | MVa (95% CI) | Pinteraction |
|---|---|---|---|---|
| NHS: | .992 | |||
| 0 | 26 | 653,381 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 84 | 1,160,302 | 1.46 (0.93–2.27) | |
| 5–14.9 | 55 | 528,005 | 1.83 (1.13–2.97) | |
| ≥15 | 40 | 260,514 | 2.71 (1.62–4.52) | |
| NHSII: | ||||
| 0 | 21 | 497,945 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 55 | 1,226,014 | 0.95 (0.57–1.58) | |
| 5–14.9 | 56 | 532,497 | 2.00 (1.18–3.37) | |
| ≥15 | 15 | 135,665 | 1.80 (0.91–3.58) | |
| Age ≤ 50 years: | .620 | |||
| 0 | 34 | 729,772 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 101 | 1,740,450 | 1.09 (0.74–1.62) | |
| 5–14.9 | 79 | 773,763 | 1.68 (1.11–2.55) | |
| ≥15 | 42 | 242,217 | 2.47 (1.54–3.96) | |
| Age > 50 years: | ||||
| 0 | 13 | 421,553 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 38 | 645,866 | 1.56 (0.82–2.94) | |
| 5–14.9 | 32 | 286,739 | 2.62 (1.34–5.11) | |
| ≥15 | 13 | 153,962 | 2.00 (0.90–4.43) | |
| BMI ≤ 25 kg/m2: | .263 | |||
| 0 | 20 | 458,945 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 67 | 970,100 | 1.39 (0.84–2.31) | |
| 5–14.9 | 69 | 555,509 | 2.26 (1.35–3.77) | |
| ≥15 | 27 | 228,502 | 1.98 (1.09–3.60) | |
| BMI > 25 kg/m2: | ||||
| 0 | 27 | 692,381 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 72 | 1,416,216 | 1.11 (0.70–1.74) | |
| 5–14.9 | 42 | 504,993 | 1.71 (1.03–2.83) | |
| ≥15 | 28 | 167,678 | 3.28 (1.89–5.70) | |
| <2 NSAID tables per week: | .312 | |||
| 0 | 16 | 698,150 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 55 | 1,193,189 | 1.74 (0.99–3.07) | |
| 5–14.9 | 31 | 498,979 | 2.07 (1.11–3.86) | |
| ≥15 | 23 | 196,641 | 3.62 (1.86–7.05) | |
| ≥2 NSAID tablets per week: | ||||
| 0 | 31 | 453,175 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 84 | 1,193,127 | 0.97 (0.64–1.48) | |
| 5–14.9 | 80 | 561,523 | 1.77 (1.15–2.72) | |
| ≥15 | 32 | 199,538 | 1.80 (1.08–3.01) | |
| Never smoker: | .171 | |||
| 0 | 28 | 776,512 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 64 | 1,320,582 | 1.22 (0.78–1.91) | |
| 5–14.9 | 39 | 468,628 | 1.89 (1.15–3.12) | |
| ≥15 | 14 | 114,702 | 2.69 (1.40–5.18) | |
| Prior or current smoker: | ||||
| 0 | 19 | 374,814 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 75 | 1,065,734 | 1.19 (0.71–1.97) | |
| 5–14.9 | 72 | 591,874 | 1.87 (1.12–3.13) | |
| ≥15 | 41 | 281,478 | 2.22 (1.28–3.87) | |
| MHT non-user: | .267 | |||
| 0 | 15 | 693,031 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 37 | 1,267,432 | 1.11 (0.60–2.05) | |
| 5–14.9 | 35 | 519,451 | 2.25 (1.19–4.24) | |
| ≥15 | 14 | 186,555 | 2.47 (1.16–5.29) | |
| MHT user: | ||||
| 0 | 32 | 458,295 | 1.00 (1.00–1.00) | |
| 0.1–4.9 | 102 | 1,118,884 | 1.24 (0.83–1.85) | |
| 5–14.9 | 76 | 541,051 | 1.83 (1.19–2.81) | |
| ≥15 | 41 | 209,624 | 2.30 (1.42–3.72) |
Abbreviations: BMI, body mass index; CI, confidence interval; MHT, menopausal hormone therapy; MV, multivariable; NHS, Nurses’ Health Study; NHSII, Nurses’ Health Study II; NSAIDs, nonsteroidal anti-inflammatory drugs.
aAdjusted for age, body mass index, menopausal hormone therapy, physical activity, nonsteroidal anti-inflammatory drug use, smoking status, Alternative Healthy Eating Index, and cohort, minus the selected strata.