Table 2.

Univariate and Multivariate Logistic Regression Analysis of LMD for all Patients with MBM

Univariate
Covariate	Level	N	Odds Ratio(95% CI)	OR P-value	Overall P-value
Gender	Female	280	1.69 (1.04–2.75)	.033	.033
	Male	547	-	-
Dural metastasis	Yes	49	2.52 (1.17–5.43)	.018	.018
	No	769	-	-
Intraventricular metastasis	Yes	23	6.06 (2.48–14.84)	<.001	<.001
	No	804	-	-
Tumor bordering ventricle/cistern	Yes	192	3.73 (2.28–6.10)	<.001	<.001
	No	635	-	-
Number of lesions bordering ventricle/cistern	>2	17	4.97 (1.55–16.00)	.007	<.001
	2	28	4.41 (1.68–11.53)	.003
	1	147	3.47 (2.03–5.95)	<.001
	0	635	-	-
Location of brain metastasis	Infratentorial/ Both	162	1.39 (0.79–2.43)	.254	.254
	Supratentorial	665	-	-
Chemotherapy before initial MBM diagnosis	Yes	181	0.68 (0.36–1.29)	.241	.241
	No	646	-	-
Chemotherapy after initial MBM diagnosis	Yes	392	1.77 (1.08–2.89)	.022	.022
	No	435	-	-
Immune therapy before initial MBM diagnosis	Yes	342	1.12 (0.69–1.81)	.652	0.652
	No	485	-	-
Immune therapy after initial MBM diagnosis	Yes	390	0.76 (0.47–1.24)	.278	.278
	No	437	-	-
Craniotomy for tumor resection	Yes	375	1.19 (0.74–1.93)	.476	.476
	No	452	-	-
Radiation for all metastasis	SRS/FSRT	470	0.77 (0.43–1.38)	.382	.592
	WBRT ± SRS	190	0.71 (0.35–1.46)	.349
	None	167	-	-
Radiation for metastasis bordering ventricle	SRS/FSRT	95	0.61 (0.26–1.45)	.267	.073
	WBRT ± SRS	59	0.28 (0.09–0.83)	.022
	None	38	-	-
Multivariate
Covariate	Level		Odds Ratio(95% CI)	OR P-value	Overall P-value
Gender	Female		1.69 (1.02–2.81)	.042	.042
	Male		-	-
Dural metastasis	Yes		2.33 (1.04–5.23)	.041	.041
	No		-	-
Intraventricular metastasis	Yes		4.48 (1.72–11.70)	.002	.002
	No		-	-
Tumor bordering ventricle/cistern	Yes		3.17 (1.90–5.30)	<.001	<.001
	No		-	-