Table 4.
Univariate and Multivariate Logistic Regression Analysis of LMD for Nonsurgical Patients with MBM
| Univariate | |||||
|---|---|---|---|---|---|
| Covariate | Level | N | Odds Ratio(95% CI) | OR P-value |
Overall P-value |
| Gender | Female | 148 | 1.63 (0.83–3.23) | .159 | .159 |
| Male | 304 | - | - | ||
| Dural metastasis | Yes | 20 | 2.07 (0.58–7.40) | .265 | .265 |
| No | 432 | - | - | ||
| Intraventricular metastasis | Yes | 13 | 5.47 (1.60–18.71) | .007 | .007 |
| No | 439 | - | - | ||
| Tumor bordering ventricle/ cistern | Yes | 104 | 4.64 (2.33–9.24) | <.001 | <.001 |
| No | 348 | - | - | ||
| Number of lesions bordering ventricle/ cistern | >2 | 13 | 5.84 (1.47–23.20) | .012 | <.001 |
| 2 | 21 | 4.58 (1.39–15.11) | .012 | ||
| 1 | 70 | 4.44 (2.05–9.64) | <.001 | ||
| 0 | 348 | - | - | ||
| Location of brain metastasis | Infratentorial/ Both | 118 | 1.05 (0.49–2.25) | .894 | .894 |
| Supratentorial | 334 | - | - | ||
| Chemotherapy before initial MBM diagnosis | Yes | 118 | 0.90 (0.41–1.97) | .797 | .797 |
| No | 334 | - | - | ||
| Chemotherapy after initial MBM diagnosis | Yes | 220 | 2.35 (1.15–4.80) | .019 | .019 |
| No | 232 | - | - | ||
| Immune therapy before initial MBMdiagnosis | Yes | 217 | 1.16 (0.59–2.27) | .671 | .671 |
| No | 235 | - | - | ||
| Immune therapy after initial MBM diagnosis | Yes | 215 | 0.83 (0.42–1.63) | .583 | .583 |
| No | 237 | - | - | ||
| Radiation | SRS/FSRT | 264 | 0.74 (0.31–1.75) | .489 | .663 |
| WBRT ± SRS | 104 | 1.01 (0.38–2.69) | .983 | ||
| None | 84 | - | - | ||
| Tumor bordering ventricle w/o surgery | SRS/FSRT | 44 | 1.33 (0.37–4.85) | .662 | .358 |
| WBRT ± SRS | 40 | 0.57 (0.14–2.42) | .447 | ||
| None | 20 | - | - | ||
| Multivariate | |||||
| Covariate | Level | Odds Ratio(95% CI) |
OR
P-value |
Overall
P-value |
|
| Chemotherapy after initial BM diagnosis | Yes | 2.12 (1.02–4.40) | .044 | .044 | |
| No | - | - | |||
| Tumor bordering ventricle/ cistern | Yes | 4.38 (2.18–8.77) | <.001 | <.001 | |
| No | - | - | |||