Table 1.
Model input values
| Model input | Base case | One-way sensitivity analysis |
|---|---|---|
| Direct medical costs, $∗ | ||
| Hospitalization, per admission | 16,491 | 14, 687; 22,066 |
| Fecal calprotectin test, per test | 40.00 | N/A |
| CRP test, per test | 10.15 | 3.72; 16.60 |
| Adalimumab, per 40 mg dose | 785.45 | N/A |
| Biosimilar discount rate, % | 0 | 0; 40 |
| Health state distribution, % | ||
| Moderate | 74 | 0; 100 |
| Severe/very severe | 26 | 100; 0 |
| Model time horizon, weeks | 260 | 48, 260 |
| Annual discount rate, % | 1.5 | 0; 3.0 |
| Indirect costs | ||
| Hourly wage, $∗ | 29.51 | 24.10; 32.73 |
| Average hours per working week, h | 36.9 | 34.8; 37.2 |
Data sources for direct and indirect costs are presented in Supplementary Tables 3 and 4. CRP, C-reactive protein.
All costs are in 2020 Canadian dollars.