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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Chem Biol Interact. 2020 Nov 10;333:109321. doi: 10.1016/j.cbi.2020.109321

Fig. 1. RNA and DNA in situ hybridization of oral papilloma/tumor tissues (Mouse 1–3 UOM) showing papillomavirus origin of tumor tissue.

Fig. 1.

(A) lower magnification (40X) of tumor with RNA in situ for viral E4 transcripts (brown stain). Insert images show viral DNA signal in benign papilloma (D) and viral RNA in papilloma tissue (E). (B) DNA in situ hybridization (200X) showing tumor area with rare weakly-staining nuclei (blue stain) indicating reduced viral DNA copy numbers compared to benign papilloma tissue (D). (C) RNA in situ hybridization (200X) of the tumor showing areas of viral RNA staining (brown) as well as areas of reduced staining compared to benign papilloma (E). Representative tumor tissue from group 1 mouse.