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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: J Proteome Res. 2021 Oct 20;20(12):5227–5240. doi: 10.1021/acs.jproteome.1c00590

Table 1.

neXtProt protein existence evidence levels from 2012 to 2021 showing progress in identifying PE1 proteins and PeptideAtlas canonical proteins. More stringent guidelines were imposed in 2016.

PE Level 2012-02 2013-09 2014-10 2016-01 2017-01 2018-01 2019-01 2020-01 2021-02
1: Evidence at protein level 13,975 15,646 16,491 16,518 17,008 17,470 17,694 17,874 18,357
2: Evidence at transcript level 5205 3570 2647 2290 1939 1660 1548 1596 1265
3: Inferred from homology 218 187 214 565 563 452 510 253 147
4: Predicted 88 87 87 94 77 74 71 50 9
MP = PE2 + PE3 + PE4 5511 3844 2948 2949 2579 2186 2129 1899 1421
 
Human PeptideAtlas canonical proteins 12,509 13,377 14,928 14,569 15,173 15,798 16,293 16,655 16,702
a

PE1/PE1+2+3+4 = 18,357/19,778 = 92.8%

b

PE 2+3+4 = 1421 "missing proteins" as of 2021-02.