Fig. 4.
APOE4 is associated with increased COVID-19 incidence and serum indicators of inflammation. a The percentage of APOE ε3ε4 carriers in healthy populations (gray) and COVID-19 patient (pink) cohorts based on Jia et al. and our results combined.8 b–o Serum samples from a Chinese cohort of COVID-19 patients with APOE ε3/ε3 (n = 102) and ε3/ε4 (n = 40) genotypes were collected within the acute phase during hospitalization, and concentrations of cytokines and chemokines in serum samples were determined by ELISA. Box plots represent median, first and third quartiles; Whiskers represent 1.5x the IQR (interquartile range) above and below the box. Data are presented as mean ± S.E.M. Unpaired, two-sided Mann–Whitney U-tests were used to evaluate statistical significance. *P < 0.05; **P < 0.01; ***P < 0.001